firstname.lastname@example.orgJidian Building 1113, Haidian District, Xueyuan Road 30, Beijing, China 100083
- Beijing Institute of Technology
- Applied Mechanics
- Professor Gengkai Hu
- The Hong Kong University of Science and Technology
- Mechanical Engineering
- Professor Qingping Sun
2017/06- Present Professor
2012/07-2017/06 Associate Professor
2008/01-2012/06 Assistant Professor
- University of Science and Technology Beijing
- School of Mechanical Engineering
- Biofilms, Phase transitions in biological systems.
2013/09- Present Visiting Scholar
- Harvard University
- School of Engineering and Applied Science
- Biofilm physics, microfluidics.
2013/02-2013/08 Visiting Scholar
- Northwestern University
- Department of Civil and Environmental Engineering
- Soft electrical materials.
- The University of Hong Kong
- Orthopaedics and Traumatology
- Professor Weijia Lu (William)
- Mechanics of the nanofiber reinforced composite bone cement.
Current Research Interests:
· Phenotypic observation and quantification in bacterial biofilms
· Self-healing of Biofilms
· The heterogeneity of biofilm growth
· Phase transitions in bio-systems
Major Research Accomplishments:
· Developed a straightforward, non-invasive imaging technique to track biofilm growth and phenotype switches of Bacillus subtilis biofilms
· Developed a fluorescence microscopy method to analyze bacterial biofilm growth, distribution of phenotypes and the fraction of non-fluorescing material
· Developed an image correlation method to track surface motion of biofilms
· Developed a calibration procedure involving cross-sectioning of biofilms to estimate biofilm thickness for transmission images
· Developed the Ginzburg Landau theory for bacterial flagellar phase transition
· Complemented Finite Element Method to simulate the bacterial flagellar phase transition characteristics such as phase nucleation, phase growth, phase propagation and loading-rate dependent phase transitions
· Phase transitions in Nature Fall
· Bio-mechanics Fall
1. National Natural Science Foundation of China Project - The mechanobiology of bacterial biofilm self-healing (2020-2023), PI.
2. National Natural Science Foundation of China Project - Multi-scale and Heterogeneous Mechanics in the Bacterial biofilm (2018-2021), PI.
3. National Natural Science Foundation of China – Key international collaborating Project – Mechanobiology of Embryonic Stem Cell Differentiation (2017-2021), co-PI.
4. National Natural Science Foundation of China Project - Rate-dependent bacterial flagellar phase transition and motion – Multi-scale of size and time effects (2013-2016), PI.
5. National Natural Science Foundation of China Project – The mechanical modeling of the phase transition in the bacterial flagellar filament (2010-2012), PI.
6. Opening fund of State Key Laboratory of Nonlinear Mechanics – The mechanical analysis of the biofilm streamer nucleation and geometry characterization in microfluidic channels. (2016), PI.
7. Beijing Higher Education Young Elite Teacher Project – Multiple length scale and non-local problems in bacterial flagellar filament phase transition. (2013-2015), PI.
8. The Fundamental Research Funds for the Central Universities – Multi-field problems of metal phase transition during the annealing. (2012-2013), PI.
Awards and Honors:
· China Scholarship Council 2012
· Excellent graduate 2000, 2003
· Hua Neng Jing Gong University Scholarship 2001
· People’s Scholarship 1996-2000
· Excellent student 1999, 2000
· Member of Biophysical Society
· Member of CSTAM (The Chinese Society of Theoretical and Applied Mechanics)
· Local member of the organization committee of IUTAM (The International Union of Theoretical and Applied Mechanics) Symposium in 2004 held in HKUST.
· Member of HKSTAM (The Hong Kong Society of Theoretical and Applied Mechanics)
1. Xiaoling Wang, Yifan Tan, JiaLi Liu, Shuaishuai Hu, Hui Zhao. The Evolving Wrinkle Pattern of The Bacillus Subtilis Biofilm Providing More Living Space for Cells. Journal of Mechanics in Medicine and Biology. 2020, 20 (7), 2050048.
2. Xiaoling Wang, Yuhao Kong, Hui Zhao and Xiaoqiang Yan. Dependence of the Bacillus subtilis biofilm expansion rate on phenotypes and the morphology under different growing conditions. Development Growth and Regeneration. September 2019, 61, (7-8), 431-443. DOI: 10.1111/dgd.12627
3. Hui Zhao, Xuan Li, Wencheng Wang, Xiaoling Wang, Shaodong Wang, Na Lei, Xiangfeng Gu. Polycube Shape Space. Pacific Graphics 2019, 2019, 38 (7), 1-12.
4. Xiaoling Wang, Zhaocan Wang, Xing Shen, Yuhao Kong, Hui Zhao, Xiaoqiang Yan. Studying the internal stress heterogeneity of the growing biofilm by the micropillar deformation of the growing substrate. Journal of Mechanics in Medicine and Biology. 2019, 19(06), 1950070. DOI: 10.1142/S0219519419500702
5. Xiaoling Wang, Xing Shen, Zhaocan Wang, Yuhao Kong. Viscoelasticity variation in a biofilm-mediated Bacillus subtilis suspension induced by adding polyethylene glycol. European Biophysics Journal, 2019, 48(7), 599-608. DOI 10.1007/s00249-019-01385-0
6. Hui Zhao, Kehua Su, Chenchen Li, Boyu Zhang, Lei Yang, Na Lei, Xiaoling Wang, Steven J. Gortler, Xianfeng Gu. Mesh Parameterization Driven by Unit Normal Flow. COMPUTER GRAPHICS Forum 2019. https://doi.org/10.1111/cgf.13660
7. Hui Zhao, Xuan Li, Huabin Ge, Na Lei, Min Zhang, Xiaoling Wang, Xianfeng Gu. Conformal mesh parameterization using discrete Calabi flow. Computer Aided Geometric Design 2018, 63, 96-108. DOI: 10.1016/j.cagd.2018.03.001
8. Xiaoling Wang, Kai Zhao and Hui Zhao. Finite Element Simulation of Biofilm Viscoelastic Behavior under Various Loadings. Journal of Mechanics in Medicine and Biology. 2018, 18(5), 1850056. DOI: 10.1142/S0219519418500562
9. Siddarth Srinivasan, Ioana D. Vladescu, Stephan A. Koehler, Xiaoling Wang, Madhav Mani, and Shmuel M. Rubinstein. Matrix Production and Sporulation in Bacillus subtilis Biofilms Localize to Propagating Wave Fronts. Biophysical Journal 114, 1–9, March 27, 2018. https://doi.org/10.1016/j.bpj.2018.02.002
10. Cheng Zhang, Bo Li, Jing-Ying Tang, Xiaoling Wang, Zhao Qin and Xi-Qiao Feng. Experimental and theoretical studies on the morphogenesis of bacterial biofilms. Soft Matter, 2017, 13 (40), 7389-7397. DOI:10.1039/C7SM01593C
11. Xiaoling Wang, Shuo Meng and Jingshi Han. A Continuum Theoretical Model and Finite Elements Simulation of Bacterial Flagellar Filament Phase Transition. Journal of Biomechanics, 2017, 63, 21–31. DOI: http://dx.doi.org/10.1016/j.jbiomech.2017.09.012
12. Xiaoling Wang, Shuo Meng and Jingshi Han. Morphologies and phenotypes in Bacillus subtilis biofilms. Journal of Microbiology (2017) Vol. 55, No. 9, pp. DOI 10.1007/s12275-017-7041-z
13. Xianlong Zhang, Xiaoling Wang, Qingping Sun. Modeling of Biofilm Growth on Ager Substrate Using the Extended Finite Element Method. Procedia IUTAM, 2017 (23), 33-41. doi: 10.1016/j.piutam.2017.06.003
14. Xianlong Zhang, Xiaoling Wang, Kai Nie, Mingpeng Li, Qingping Sun. Simulation of Bacillus subtilis biofilm growth on agar plate by diffusion reactionbased continuum model. Physical Biology 13(4):046002 · July 2016. DOI: 10.1088/1478-3975/13/4/046002
15. Jun-ichi Matsushita, Tatsuki Satsukawa, Naoya Iwamoto, Xiaoling Wang, Jianfeng Yang, Tomoyo Goto, Tohru Sekino, Xiaoyong Wu, Shu Yin, and Tsugio Sato. Oxidation of Pentatitanium Trisilicide (Ti5Si3) Powder at High Temperature. Materials Science Forum, 868, 38-42 (2016), DOI: 10.4028/www.scientific.net/MSF.868.38
16. Xiaoling Wang, Mudong Hao, Xin Du, Guoqing Wang, Junichi Matsushita. The mechanical analysis of the biofilm streamer nucleation and geometry characterization in microfluidic channels. Computational and Mathematical Methods in Medicine. 2016: 1-10. http://dx.doi.org/10.1155/2016/7819403.
17. Xiaoling Wang, Stephan A. Koehler, James N. Wilking，Naveen N. Sinha, Matthew T. Cabeen, Siddarth Srinivasan, Agnese Seminara, Shmuel Rubinstein, Qingping Sun, Michael P. Brenner, David A. Weitz. Probing Phenotypic growth in expanding Bacillus subtilis biofilms. Applied Microbiology and Biotechnology, 2016, 100(10), 4607-4615. DOI: 10.1007/s00253-016-7461-4.
18. Xiaoling Wang, Han JS, Li Kui, Wang GQ and Hao MD, Multi-Layer composite mechanical modeling for the inhomogeneous biofilm mechanical behavior, Computational Biology and Chemistry, 2016, 14(4), 1650014-(1-14). DOI: http://dx.doi.org/10.1142/S0219720016500141
19. Matsushita J, Tsuchiyama T, Hamaguchi K, Iwamoto N, Xiaoling Wang, Yang JF, Sekino, Wu XY, Yin S, and Sato T, Anatase Type Titanium Dioxide Prepared by Oxidation of Titanium Carbide, Materials Science Forum, 2016, Vol. 860, 92-96. DOI: 10.4028/www.scientific.net/MSF.860.92
20. Xiaoling Wang, Hao MD and Wang GQ, Numerical simulation of wrinkle morphology formation and the evolution of different Bacillus subtilis biofilms, Water Science and Technology, 2016, 73(3), 527-534. DOI: 10.2166/wst.2015.486
21. Xiaoling Wang, Hou YR, Wang GQ Hao MD and Li H, Parametric Optimization of Metal Conductors in Flexible Electronics Design, Circuit World, 2016, Vol.42 (2), 89-94. DOI:10.1108/CW-08-2015-0043.
22. Dong L, Zhou RH, Xiaoling Wang, Hu GK, Sun QP, On interfacial energy of macroscopic domains in polycrystalline NiTi shape memory alloys, International Journal of Solids and Structures, 2016, 80, 445-455.
23. Xiaoling Wang, Wang GQ and Hao MD, Modeling of the Bacillus subtilis Bacterial Biofilm Growing on an Agar Substrate, Computational and Mathematical Methods in Medicine. 2015, 9, 1-10, DOI:10.1155/2015/581829
24. Xiaoling Wang, Hao L and Wang GQ, Effect of the geometric parameters of elastomer substrates on the flexibility of stretchable electronics, Chinese Journal of Engineering, 2015, 37 (s1), 24-28
25. Xiaoling Wang, and Q. P. Sun, Modeling of rate-dependent phase transition in bacterial flagellar filament，Materials Research Bulletin, Materials Research Bulletin, 2013, 43, 5019-5025. DOI: 10.1016/j.materresbull.2013.05.009.
26. Xiaoling Wang, Sun QingPing. Mechanical Analysis of Phase Transition Experiments of the Bacterial Flagellar Filament. Acta mechanica Sinica, 2010, 26 (5), 777-785.
27. Xiaoling Wang, Sun QingPing. The review of phase transition in biological systems. Advances in Mechanics, 2010 ,40 (1): 64-80 (in Chinese).
28. Xiaoling Wang, Sun QingPing. Mechanical modeling of the bistable bacterial flagellar filament. Acta Mech Solida Sinica, 2011. 24(S), 1-16.
29. Xiaoling Wang, Yongjun He, Sun QingPing. Simulation of Bacterial flagellar phase transition by non-convex and non-local continuum modeling. Theoretical & Applied Mechanics Letters. 2011, 1 (4): 044001-6.
30. Xiaoling Wang, Hu GengKai. Stress transfer for a SMA fiber pulled out from an elastic matrix and related bridging effect. Composites part A - Applied Science and Manufacturing, 2005, 36 (8): 1142-1151.
31. Xiaoling Wang, Zhao H, Virtual Medical Model Modification with Laplacian System, International Conference on Biomedical Engineering & Informatics, 2010, 3(1), 1296-1299.
32. Xiaoling Wang, Zhang Q, The Mechanical Property Analysis of Circular Saw Blades under Different Rotational Speeds, Advanced Materials Research, 2010, 145, 365-370.
33. Xiaoling Wang, Zhang Y, The Analysis on Different Circular Saw Structures for Reducing Saw Noise, Advanced Materials Research. 2010, 145, 551-556.
34. Xiaoling Wang, Zhao H, Surface Based Virtual Mechanical Equipment Modification, Advanced Materials Research, 2010, 149, 693-697.
35. Xiaoling Wang, Zhao H, Virtual Mechanical Equipment Model Smoothing, Advanced Materials Research, 2010, 156, 355-359.
36. Xiaoling Wang, Yin ZJ and Li YL, The stress analysis of different circular saw structures during cutting, Advanced Materials Research. 2011, 228, 471-476.
37. Xiaoling Wang, Yin ZJ and Zhang C, The analysis of dynamic characteristics in reduction of the circular saw idling noise, Advanced Materials Research, 2011, 229, 477-483.
38. Xiaoling Wang, Yin ZJ and Zhang C, The mechanical analysis of the composite reinforced circular saw blade, Advanced Materials Research, 2011, 228: 484-489.
1. Xiaoling Wang, David A. Weitz. Experimental method for improving the output power of microbial fuel cells using droplet microfluidic technology. May 27, 2017.
2. Xiaoling Wang, David A. Weitz. Experimental method for real-time observation of the number and distribution of different gene phenotype cells during the growth of Bacillus subtilis biofilms. February 24, 2018.
Conference presentations and proceedings:
1. 2009, August 21-22, Damage, Fracture and Micro/Nano Mechanics Conference. Beijing, China.
2. 2009, August 24-26, The Chinese Congress of Theoretical and Applied Mechanics (CCTAM) 2009, Zhengzhou, China.
3. 2009, October 11-15, The Chinese Congress of Biomechanics. Tianjin, China
4. 2010, April 23-25, The 3rd Jishuitan Orthopedics Forum, China National Convention Center, Beijing, China.
5. 2010, July 18-24, NSFC advanced work shop on frontiers of biomaterials and cell mechanics, Tsinghua University, Beijing.
6. 2010, August 26-27, The 6th Beijing International Symposium on Biomechanics, Beijing University of Technology, Beijing. Talk title: “Mechanical Modeling of Phase Transition in Bacterial Flagellar Filaments”.
7. 2010, October 22-24, Chinese Multi-Scale Mechanics Conference, Beijing Xiangshan Mountain.
8. 2010, November 11-14, 2010 Chinese solid mechanics Conference for celebrating 30 anniversaries of Acta mechanica Solida Sinica, Huazhong Science and Technology University, Wuhan, Hubei, China.
9. 2012, May 28 - Jun 3, NSF summer workshop on “Materiomics: Merging Biology and Engineering in Multiscale Structures and Materials”, Boston, USA.
10. 2012, August 15-18, IUTAM Symposium in Hong Kong on "Hysteresis and pattern evolution in non-equilibrium solid-solid phase transitions", Talk Tile: “Simulation of bacterial flagellar phase transition by non-convex and non-local continuum modeling, Hong Kong.”
11. 2012, December 11-15, the 10th National Conference on Biomechanics and 12ed National Conference on Biorheology. Chengdu China. Talk Title: Simulation of bacterial flagellar phase transition by non-convex and non-local continuum modeling
12. 2012, December 17-20, The 5 International Symposium on Functional Materials, Perth, Western Australia, Poster: Stability Analysis and FEM Simulation of Polymorphic Phase Transition in Bacterial Flagellar Filament.
13. 2013, June 10-12, NATIONAL SCIENCE FOUNDATION Summer Institute on Nanomechanics and Nanomaterials and Micro/Nanomanufacturing, “The Materials Genome: Current Practice and Future Promise”. Evanston, Illinois, USA.
14. 2013, September 18, 56th NECF workshop at WPI Boston, Boston, USA.
15. 2013, December 13, the 57th New England Complex Fluids Workshop, Boston University, Boston, USA.
16. 2014, June 12-13, Boston Bacterial Meeting, Harvard University. Cambridge, USA.
17. 2015, October 10-14, 11th National Conference on Biomechanics and 13th National Conference on Biorheology, Taiyuan, China.
18. 2016, Jan 6-7, Topical Research Meeting on Physical Principles of Biological and Active Systems, Edinburgh, UK.
19. 2016, May 23-25, International Workshop on Molecular - Cell and Tissue Mechanobiology, Tsinghua University, Beijing, China. Invited talk: “ The phenotype evolution and mechanics of the Bacillus subtilis biofilm”
20. 2016, June 5-10, Gordon Research Conference “Bioinspired Materials”, Les Diablerets, Switzerland. Poster presenter ‘Probing Phenotypic growth in expanding Bacillus subtilis biofilms’.
21. 2016, June 12-17, Gordon Research Conference “Biointerface Science”, Les Diablerets, Switzerland. Poster presenter ‘Numerical simulation of wrinkle morphology formation and the evolution of different Bacillus subtilis biofilms’.
22. 2017，Feb 4-12, Gordon Research Conference” Physical Science of Cancer”, Galveston, TX. Poster presenter’ Modeling of rate-dependent phase transition in bacterial flagellar filament’.
23. 2017, May 8-14, Biofilm 2017- 10th International Conference on Biofilm Reactors, University of College Dublin, Ireland. Poster presenter ‘Probing Phenotypic growth in expanding Bacillus subtilis biofilms’.
24. 2017, June 16, 2017, 71st New England Complex Fluids Workshop at Tufts University, Boston, USA.
25. 2017, Aug. 6-8, Visiting Department of Mechanical and Materials Engineering and Biomedical Engineering Program, Western University (The University of Western Ontario), Canada.
26. 2017, Nov. 29 - Dec. 1, The 4th World Congress and Expo on Applied Microbiology, Madrid, Spain. Talk Title: Phenotypes and Mechanical Properties of Bacillus subtilis biofilms.
27. 2018, April 17-23, A Symposium on Soft Matter Forefronts. Georgia Institute of Technology, Atlanta, GA USA.
28. 2018, May 27-29, Biofilms 8 Conference, Aarhus University, Denmark.
29. 2018, June 17-22, Gordon Research Conference- Biointerface Science: Surfaces and Compartments in Biology and Medicine, Renaissance Tuscany Il Ciocco Lucca (Barga), Italy.
30. 2018, June 24-29, Gordon Research Conference- Bioinspired Materials: Bioinspired Multifunctional Dynamic Materials, Les Diablerets Conference Center, Les Diablerets, Switzerland.
31. 2018, Nov. 23-25, 2018 Solid mechanics, Haerbin, Heilongjiang, China. Invited talk: “The internal stress in the biofilm growth”.
32. 2019, Jan. 6-11, Gordon Research Conference- Stochastic Physics in Biology: Fluctuations, Landscapes and Statistical Mechanics of Biological Heterogeneity, Four Points Sheraton / Holiday Inn Express, 1050 Schooner Drive, Ventura, CA, US.
33. 2019, Oct. 14-17, Pacific Graphics 2019, Seoul, Korea.
34. 2019, Nov. 15-17, 2019 Fracture mechanics and its applications, Chengdu, Sichan. Invited talk: “The self-healing of biofilms”
35. 2020, Oct. 9-11，Symposium on Frontiers of Cell and Tissue Evolution Dynamics, Beijing Convention Center, Beijing, China. Invited talk: ”Phase transitions in the biofilm”.